Cleaning Validation of Albendazole Tablets 400 mg

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

website: www.thepharmajournal.com

Author: Bodavula Samba Siva Rao, Y. Surendhranath Reddy, M. Jeybaskaran

Abstract: The cleaning validation is to verify the effectiveness of the cleaning procedure for removal of product residues, degradation products, preservatives, excipients and cleaning agents so that the analytical monitoring may be reduced to a minimum in the routine phase. In addition one need to ensure there is no risk associated with cross contamination of active ingredients. Cleaning validation is intended to address special consideration and issues pertaining to validation cleaning procedures for equipment used in the manufactured of pharmaceutical products, radiopharmaceuticals, and biological drugs. The document is also intended to establish inspection consistency and uniformity with respect to equipment cleaning procedures.

Keyword: Acceptable residual level (ARL), Cleaning equipment, Swabs and Wipes Method, Rinse Method

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Transdermal Drug Delivery System: A Review

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

website: www.thepharmajournal.com

Author:Dipen Patel*, Sunita A. Chaudhary, Bhavesh Parmar, Nikunj Bhura

Abstract: A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered in this method. A wide variety of pharmaceuticals are now available in transdermal patch form.

Keyword: transdermal drug delivery system, bioavability, Iontophoresis, Electroporation, ultrasound, microscopic projection

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Recent Trends in Medicinal Uses and Health Benefits of Indian Traditional Herbs Aegle Marmelos

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

website: www.thepharmajournal.com

Author: K.P.Sampath kumar*, M.Umadevi, Debjit Bhowmik, Durgesh Mohan Singh, A.S. Dutta

Abstract: Nature produces several food items for every season. Their use in that particular season proves to be highly beneficial for our body and the entire state of health. Bael fruit is one such blessing from nature for the mankind which is packed with enormous medicinal advantages. The Bael (Aegle marmelos) is one of the most useful medicinal plants of India. Its medicinal properties have been described in the ancient medical treatise in Sanskrit, Charaka Samhita. All parts of this tree—stem, bark, root, leaves and fruit at all stages of maturity —have medicinal virtues and have been used as medicine for a long time. The fruit's medicinal value is very high when it just begins to ripen. The fruit is aromatic, cooling and laxative. It arrests secretion or bleeding. The unripe or half-ripe fruit is good for digestion. It is useful in preventing or curing scurvy. It also strengthens the stomach and promotes its action. In recent times, focus on plant research has  increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Over the last few years, researchers have aimed at identifying and validating plant derived substances for the treatment of various diseases. Similarly it has been already proved that various parts of plants such as Leafs, fruits, seeds etc.  provide health and nutrition promoting compounds in human diet. Bael  fruit is popularly used in diarrhea, dysentery and GI disorders and has digestive and carminative properties. It helps in the healing of ulcerated intestinal surfaces. It possesses anti-viral, anthelmintic and anti-inflammatory properties and has appreciable activity against intestinal pathogenic organisms.

Keyword: Aegle Marmelos, Medicinal Uses and Health Benefits

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A Review on Osmotically Regulated Devices

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

website: www.thepharmajournal.com

Author: Bharat parashar, Brajesh maurya*, Virendra yadav, Love sharma

Abstract: Osmosis is physical phenomenon that has been extensively studied by scientist in various disciplines of science and engineering .osmotic devices are the most promising strategy based system for controlled drug delivery. Convention drug delivery has little control over their drug release and almost no control over the effective concentration at the target site .this kind of dosing pattern may result in constantly changing unpredictable plasma concentration. Drug can be delivered in a controlled over a long period of time by the process of osmosis. Osmotic pump offers may advantages over other controlled relase devices i.e. they are easy to formulated and in simple operation, improve patient compliance with reduced dosing frequency and prolong therapeutic effect with uniform blood concentration. They are most reliable controlled drug delivery system is not influenced by different physiological factor with in the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the doses form. In this paper, various type of osmotically controlled pump with basic component and factor affecting have been discussed briefly.

Keyword: osmotic pump, semipermeable membrane, wicking agent, osmogen , leachable pore former

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Natural Therapy of Fungal Nail Disease: Review

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

website: www.thepharmajournal.com

Author: Dr.Bharat parashar, Virendra yadav, Brajesh maurya, Love sharma

Abstract: Nails are the unique part of body, besides it’s a dead tissue it also have role in serving the human beauty. It protects the fingertip and tissues from injuries and also enhances the precise movements of distal digits, but it has also been cursed with many diseases and ailments including serious infections. Most common types are of Fungal or Yeast infections resulting in Onychomycosis and if it is left untreated, the nail plate may separate from the nail bed. Other infections include Paronychia, Tinea Unguis, and Pseudomonas bacterial infection. Different nail disorders are Onychatrophia resulting from injury, Leuconychia cause by trapping of tiny bubbles of air, Melanonychia known as nail moles and can be sometimes serious. For a physician physical appearance of nail is important which can reveals many disorders like Malnutrition, Liver disease, etc. Nail infections can be treated with natural products which are mainly Oregano oil, Lemongrass oil, Horopito. One of the latest and modern treatment to treat fungal infections of nails is Ozone treatment but it is not frequently used and quite costly. Like others body parts nails also required a good source of nutrients to maintain their complexions and healthiness, Vitamin A , Vitamin D and calcium help in maintaining moisture content of nails and avoid brittleness, Besides this Proteins and fatty acids like Linoleic acids are also essential.

Keyword: Nails, Fungal Infection ,Natural Treatment

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Pharmacological Treatment of Depression, Based On Survey in Different Hospitals and Clinics

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

website: www.thepharmajournal.com

Author: Bharat parashar, Virendra yadav,  Brajesh maurya, Love sharma

Abstract: Feeling down from time to time is a normal part of life but when emptiness and despair take hold and won’t go away, it may be depression - “living in a black hole” or having feeling of impending doom. Symptoms - you can’t sleep or you sleep too much, you can’t concentrate or find that previously easy tasks are now difficult, you feel hopeless and helpless, you can’t control your negative thoughts, no matter how much you try, you have lost your appetite or you can’t stop eating. Non-pharmacological treatment should involve exercise, psychotherapy, supplements and your pleasures, etc. Exercise has been found to be most effective treatment for depression and the minimum recommendation is three times per week for 20 minutes. Weekly psychotherapy and a check on your pleasures like coffee, alcohol, sugar and recreational drugs, and supplements like taking fish oil for omega-3, fatty acid daily, St. John’s Wort, and vitamins-B12, etc. Direct exposure to sunlight every day is very helpful, if not possible, a light box can bring a lot of relief. Regular human contact who enjoy the same things you do, challenge your thinking, good nutrition, yoga and meditation only for mild to moderate depression. Data collected from doctors shows that 60% of doctors have opinion that 35-60 years is common age group of depression, 50% doctors said that duration of therapy depends upon patient to patient, the root cause of depression is family reasons which is admitted by 70% of doctors. The most prescribed drugs for the treatment of depression are - Imipramine 40%, Fluoxetine 30%, most prescribed drugs in pregnancy are - Fluoxetine 60%, Sertraline 20%, most prescribed drugs in lactation - Fluoxetine 70%, Amitryptiline 20% and 90% of doctors suggested that only counseling is sufficient to treat depression in children.

Keyword: Depession, Tyeps, Non pharmacological treatment, Survey data

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RP-HPLC Method Devlopment and Validation of Domperidone in Solid Dosage Form

Journal: The Pharma Innovation 
Volume: 1
Issue: 4

Author: Sharma Suparna*, Sharma Anuj Kumar, Singh Ompal, Chaturvedi Ashwani Kumar, Verma Vikrant, Arya Rajat Kumar, Singh Umesh Kumar

Abstract: A simple, accurate, reliable and reproducible HPLC method was developed for the determination of Domperidone (DOM) in solid dosage forms. The method employed C18 column, water: methanol (55:45) as mobile phase and detection was made at 291nm. The retention times was found to be 4.5 min for DOM. The method was validated as per ICH guidelines. The method shows good linearity, accuracy, and precision, limit of detection and limit of quantification.  The method was suitable for routine analysis of DOM individually and in combined dosage forms.

Keyword: HPLC, Domperidone

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