A Review on Oral Mucosal Drug Delivery System

Journal: The Pharma Innovation 
Volume: 1
Issue: 1

Author: Rakesh Hooda*, Mohit Tripathi and Prof. Kiran Kapoor

Abstract: Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for prolonged time by mucoadhesive binding. The administration of drugs by the buccal route has several advantages over per oral administration such as QWICK ACTION, improved patient compliance particularly with pediatric & geriatric patient. It is the objective of this article to review the oral mucosal drug delivery by discussing briefly the structural feature of mucosa as drug delivery such as buccoadheshive film & tablet, medicated chew gum, fast dissolving tablet, film & capsule etc.

Keyword: Buccal Drug Delivery, NDDS, Quick Action, Absorption via buccal mucosa

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Polysaccharides and Natural Gums for Colon Drug Delivery

Journal: The Pharma Innovation 
Volume: 1
Issue: 1

Author: Mohit Khandelwal*, Ankit Ahlawat and Ram Singh

Abstract: The site‐specific delivery of the drugs to the target sites has the potential to reduce the side effects and improved the pharmacological response. The colon drug targeting is also exploited for systemic delivery of active drugs. For colonic drug delivery, many physiological barriers must be overcome, the major one being absorption or degradation of the active drugs in the upper part of the GIT‐Tract. Natural polymers particularly in the form of microspheres, have an important role in the before they will have widespread use in clinical situations. Among these issues are better understanding of the kinetics of drug release; more effective ways to control burst phenomena; greater understanding of drug‐polymer interactions and their effect on shelf life stability; additional animal studies to determine local tissue response, biodegradation rates, and metabolic rate. Well‐designed Clinical studies to assess efficacy in relation to current therapies.

Keywords: Polysaccharides, Colon Drug Delivery, Pectin

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Fast Dissolving Tablet- A Review

Journal: The Pharma Innovation 
Volume: 1
Issue: 1

Author: Alok Kumar Gupta*, Anuj Mittal and Prof. K. K. Jha

Abstract: The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating"mouth dissolving tablets" (MDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area. Keyword: Fast-disintegrating tablet, Urea, Sublimation, Mouth Dissolving Tablets

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Abstracting and Indexing information

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Aim of Journal

"The Pharma Innovation" is a Peer Reviewed Journal. Prime Focus of the Journal is to publish articles related to the current trends of research. This Journal provides the platform established with the aim of motivating the students and such personals in the Pharmaceutical and Biomedical Researches and Developments.

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Purpose of Journal

The purpose of journal to publish original research work that contributes significantly to further the scientific knowledge in pharmacy sciences. Your views and comments will be highly acclaimed. Author can send their articles to jpbr.anil@gmail.com or to info@thepharmajournal.com. All manuscripts are subjected to RAPID peer review process and those of high quality (which are not previously published and are not under consideration for publication by another journal) would be published without any delay in subsequent issue. Online submission of the manuscript is strongly recommended. A manuscript number will be mailed to the corresponding author within one week or early.

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