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Journal: The Pharma Innovation
Volume: 1
Issue: 2
Author: K.P. Sampath kumar*, Debjit Bhowmik, Sweta Srivastava, Shravan Paswan and A.S.DuttaVolume: 1
Issue: 2
Abstract: Children are frequently failed to take
medications properly because of unpleasant taste of medicament.
Non‐compliance can lead to worsening of diseased condition. Numbers
of taste masking technologies have been used to address
the problem of patient compliance. Use of sweeteners, amino acids and
flavoring agents alone are often inadequate in masking the
taste of highly bitter drugs. Coating is more efficient
technology for aggressively bitter drugs even though coating
imperfections, if present, reduce the efficiency of the technique In
Ion exchange resin (IER) method weak cation exchange or weak anion
exchange resins are used for taste masking, depending on the nature of
drug. The nature of the drug resin complex formed is such that the
average pH of 6.7 and contain concentration of about 40meq/L
in the saliva are not able to break the drug resin complex but it is
weak enough to break down by hydrochloric acid present in the
stomach. Thus the drug resin complex is absolutely tasteless
with no after taste, and at the same time, its
bioavailability is not affected. Children under the age of 8 are
typically prescribed liquid medications because of smaller structure of
a child's esophagus.
